Endothelial cell autophagy in homeostasis and cancer

Autophagy, the major lysosomal pathway for degradation and recycling of cytoplasmic materials, is increasingly recognized as a player in endothelial cell (EC) biology vascular pathology. Particularly solid tumors, tumor microenvironmental stress such hypoxia, nutrient deprivation, inflammatory mediators, metabolic aberrations stimulates autophagy tumor-associated blood vessels. Increased ECs may serve mechanism to alleviate restrict exacerbated responses. However, increased can re-model pathways affect trafficking surface availability key mediators regulators interplay between EC immune cells. In line with this, heightened involved pathological angiogenesis, inflammatory, Here, we review cellular molecular mechanisms regulated by under physiological conditions discuss recent evidence implicating angiogenesis immunosurveillance.